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The concept of fibroplastic diathesis: how it appears and how to treat it

What is fibroplastic diathesis in children?

jpg width = 350 “height = 192” / gt; When considering issues of poorly differentiated connective tissue dysplasias, it is worth mentioning the problem of diathesis, which is widespread in the practice of pediatricians. And among them it is necessary to distinguish fibroplastic diathesis, which is a hereditary pathology of metabolism. Its essence consists in changing the processes of formation and maturation of the constituent components of connective tissue as a result of genetically determined breakage of enzyme systems and resulting dysplastic processes in tissues, the formation of predisposition to the appearance of pathology of the musculoskeletal system and internal organs.

In 1926 AA Bogomoltsev outlined the significant role played by connective tissue in the processes of formation of resistance and reactivity in the body. He also proposed a classification of types of constitution, which was based on an assessment of the characteristics of connective tissue. There were four types of the constitution:

  • Asthenic (with a characteristic thin and tender connective tissue);
  • Fibrous (dense and fibrous tissue);
  • Pastose (with a loose cloth);
  • Lipomatous (predominates fatty tissue).

Given the diversity and complexity of the morphological structure and functions of connective tissue, its main role in the course of many processes in the body through the active participation of its constituent elements in the formation of various pathologies. Since this fabric consists of a huge number of links that form a system. Each link in this complex is controlled by genes and is susceptible to genetic breakdown, resulting in conditions for the emergence of many genetic diseases and anomalies in which the connective tissue is afflicted.


According to the data received, external manifestations of connective tissue dysplasia are manifested in 10% of children, and this percentage increases with age. Excessive mobility in the joints, like an anomaly of the constitution, is found in 20% of adults. There is an opinion that dysplastic processes in the connective tissue of the musculoskeletal system are accompanied by unstable vegetative regulation (constitutional vegetatopathy), which leads to the development of early processes of dystrophy in the tissue of the vessels and joints.

In determining the predisposition to a given condition or diagnosis, the following factors are taken into account:

  • Pedigree of the child. It is analyzed and counted by relatives who had signs of diathesis (or connective tissue dysplasia): curvature of the spine, deformation of the chest, hypermobility of the joints, mitral valve prolapse, additional chords in the heart, etc .;
  • Clinical symptoms. Detecting clinical markers that will indicate DST: excessive and pathological mobility in joints, excessive skin stretch, skin fragility, easy vulnerability, the presence of striae, localized in various places of hernia (umbilical, inguinal, postoperative), flat feet, etc .;
  • Methods of examination. Taking into account the data of functional research, organ signs of connective tissue dysplasia (omission and disturbance of organ function, pathology of arterial, venous and mixed vessels wall, increase in trachea and bronchus size;
  • Data of laboratory analyzes. Conduct a study of the main markers, among which:

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