Gallstone disease in children
jpg width = 500 “height = 350” gt; Lipid distress syndrome as a trigger
At the present time, the theory of lipid distress syndrome has become especially popular, from the position of which the violation of fat metabolism and all the resulting various negative phenomena in organs and tissues are considered. LDS is a complex of pathological biochemical and morphological phenomena, as a result of which the exchange of fats changes, which causes a systemic reaction of the whole organism, leading to the development, in addition to a target organ, of new diseases or to the recurrence of old. The processes that occur during LDS cause a decrease in the production of substances that dilate blood vessels and disaggregants, increase the amount of inflammatory factors and platelets in the blood, increase the activity of the process of peroxidation of fats, as a result of which the mechanism of inflammation starts up and the amount of endogenous toxins increases, which is characteristic for the presence of a chronic inflammatory focus . Subsequently, transport to the cell of low density lipoproteins is disrupted, leading to their accumulation in the blood and a decrease in the concentration of polyunsaturated acids in the cells, which facilitates the transformation of inflammation into a lipid distress syndrome. Thus, LSD can be considered a phenomenon that is dependent on endogenous toxins and is associated with the process of inflammation.
This term was first used by surgeons, since it is they who most often have to deal with this pathology. A whole group of diseases is identified, for which the main etiological factor is the lipid distress syndrome. These include gallbladder cholesterosis, cholelithiasis, fatty hepatosis, lipogenic pancreatitis.